Failure of interferon alfa and tribavirin in rabies encephalitis.

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Failure of interferon alfa and tribavirin in rabies encephalitis.

OBJECTIVE To test the effect of interferon alfa and tribavirin (ribavirin) in patients with rabies encephalitis. DESIGN An open trial of chemotherapy and intensive care in patients with early rabies. SETTING The intensive care unit of a Bangkok hospital. PATIENTS Four conscious men with clinical rabies encephalitis. INTERVENTIONS Rapid virological diagnosis of rabies. Treatment with int...

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Interferon Alfa-2b Therapy in Mucocutaneous Manifestations of Behçet’s Disease

Background: Viral infections such as Epstein-Barr virus and Herpes simplex virus may play a role in the pathogenesis of Behçet’s disease (BD). Interferons (INF) are natural defense mechanisms against viruses and inhibit their activities by enhancing major histocompatibility complex class I and cytokine expression. This study evaluated the efficacy of INF-α-2b on mucocutaneous lesions of BD. Met...

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Human rabies encephalitis following bat exposure: failure of therapeutic coma.

The case: A healthy 73-year-old man had pain in his left shoulder. He presented to a regional hospital 1 week later with fever, dysphagia, muscle spasms and progressive generalized weakness. His neurologic status deteriorated , which prompted transfer to a tertiary care hospital. Upon the patient's arrival at the ter-tiary care hospital, our initial evaluation showed irritability, lethargy and ...

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MRI in rabies encephalitis.

To cite: Jain H, Deshpande A, Favaz AM, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2013201825 DESCRIPTION Human rabies leads to a mortality of 55 000 deaths/ year worldwide, out of which mortality in India is 20 000, hence is regarded as an endemic in the subcontinent. Even though rabies is definitively confirmed by the isolation of virus from biologic...

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Imaging findings in rabies encephalitis.

SUMMARY Rabies encephalitis is perhaps one of the few infectious diseases that command attention and fear not only from the layman but also from physicians. The unique mode of transmission, the virtually exclusive neurotransmission shown by the agent, and the complete hopelessness of the established disease sets rabies apart from other zoonoses transmitted to man. Rabies encephalitis is a fatal...

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ژورنال

عنوان ژورنال: BMJ

سال: 1989

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.299.6703.830